PIPERAZINE 2,5-DIONE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE

摘要

A piperazinedione of general formula (I), wherein R1 is selected from hydrogen; a group of formula -COR3 -(NH)t-COR3 wherein t is 0 or 1 and R3 is selected from (i): (A) wherein v is 0 or 1 when t is 1 and v is 1 when t is 0; and wherein n is 0, 1, 2, or 3 at least one of n and m being other than 0, and either (ii): (B) wherein p is 1 or 2 and Z is C2-C6 alkenyl or a phenyl group optionally substituted by C1-C6 alkoxy; and (iii): (C) wherein R9 is C1-C6 alkyl, pyrimidinyl or a phenyl group optionally substituted by C1-C6 alkoxy; and (F) and R2 is hydrogen or a group of formula -COR3 as defined above, provided that one or R1 and R2 is hydrogen and the other is not hydrogen; and the pharmaceutically acceptable salts thereof have activity as modulators of multidrug resistance.