LOW RIGIDITY LIPOSOMAL ANTIBACTERIAL COMPOSITION

摘要

The invention relates to a liposomal formulation containing at least one therapeutic agent such as an antibiotic and to a method of treatment of bacterial infections through the administration of such a formulation. There is provided a low rigidity multilamellar liposomal formulation, free of cholesterol, comprising a neutral lipid, an anionic lipid and at least one therapeutic agent, wherein the liposomal formulation enhances the penetration of the therapeutic agent inside a bacterial cell. A preferred lipid combination is dipalmitoylphosphatidylcholine (DPPC): dimirystoylphosphatidylglycerol (DMPG) at a ratio of 10:1 to 15:1, with total lipid concentration ranging from 5 to 85 mM.