| 摘要 |
<p>The present invention relates to cyclodextrin derivatives, and methods for the preparation thereof, which cyclodextrin derivatives have at least one but no more than N-1 'higher' alkyl groups and at least one but no more than N-1 sulfate groups, wherein the total combined number of 'higher' alkyl groups and sulfate groups does not exceed N, and further wherein N is the number of hydroxyl groups of the cyclodextrin from which the derivative was derived. The 'higher' alkyl groups are lipids and, more particularly, aliphatic or aromatic carbon chains, especially linear carbon chains having a general structure of -O-C(=O)-(CH2)n-CH3, wherein n is between 6 and 24 and/or -OC(=O)-(CH2)m-CH=CH-(CH2)m-CH3, wherein m is at least 6. The sulfate groups disclosed herein are sulfate groups having the formula -OSO3R, wherein R may be H, Na, K, Li, NH4 and/or other atoms/molecules that form monovalent cations. The CD derivatives are obtained in a two-step reaction wherein a cyclodextrin is contacted with acoylchloride followed by sulfonating SO3-complex.</p> |
