Anti-alpha V-integrin monoclonal antibody

摘要

The invention relates to a novel monoclonal antibody, a hybridoma cell line producing said antibody, DNA sequences coding for said antibody, and amino acid sequences. The monoclonal antibody, a preferred embodiment of which is named 17E6, has the following properties: -- reacting only with the alpha V-chain of human alpha V-integrins, -- blocking the attachment to the integrin substrate of the alpha V-integrin bearing cell, -- triggering reversal of established cell matrix interaction caused by alpha V-integrins, -- blocking tumor development, and -- showing no cytotoxic activity.