发明名称 LUV comprising saturated phospholipids and method of making the same
摘要 A method for encapsulation of antineoplastic agents in liposomes is provided, having preferably a high drug:lipid ratio. Liposomes may be made by a process that loads the drug by an active mechanism using a transmembrane ion gradient, preferably a transmembrane pH gradient. Using this technique, trapping efficiencies approach 100%, and liposomes may be loaded with drug immediately prior to use, eliminating stability problems related to drug retention in the liposomes. Drug:lipid ratios employed are about 3-80 fold higher than for traditional liposome preparations, and the release rate of the drug from the liposomes is reduced. An assay method to determine free antineoplastic agents in a liposome preparation is also disclosed.
申请公布号 EP0719546(A1) 申请公布日期 1996.07.03
申请号 EP19950117084 申请日期 1988.03.04
申请人 THE LIPOSOME COMPANY, INC. 发明人 BALLY, MARCEL B.;CULIS, PIETER R.;GINSBERG, RICHARD S.;MAYER, LAWRENCE D.;MITILENES, GEORGE N.
分类号 G01N33/544;A61K9/127;A61K31/505;A61K31/65;A61K31/70;A61K33/24;A61K45/08;A61K47/02;A61K47/12;A61P35/00;B01J13/02 主分类号 G01N33/544
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