发明名称 |
TREATMENT AND/OR PREVENTION OF BONE METASTASIS |
摘要 |
T-lymphocyte invasion and metastases (Tiam-1) has been identified as a marker and anti-cancer drug target for therapy of metastatic bone cancer in individuals afflicted with prostate cancer. The present disclosure provides methods and compounds for inhibiting metastases by disrupting Tiam-1 expression and activity. One particularly preferred compound comprises a disulfomanide of the formula. |
申请公布号 |
EP3041469(A1) |
申请公布日期 |
2016.07.13 |
申请号 |
EP20140776764 |
申请日期 |
2014.09.04 |
申请人 |
THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA |
发明人 |
MEUILLET, EMMANUELLE;MOSES, SYLVESTOR;ZHANG, SHUXING |
分类号 |
A61K31/4196;A61K31/433;A61K31/5365;A61K45/00;A61P35/00 |
主分类号 |
A61K31/4196 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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