EX VIVO METHODS FOR MINIMIZING RISKS AND MAXIMIZING BENEFITS OF ALLOGENEIC BLOOD AND MARROW TRANSPLANTATION

摘要

The described invention provides an ex vivo model of persistent T lymphocyte stimulation events encountered by circulating T lymphocytes at lymph node and tissue levels in vivo; a method for optimizing donor selection for allogeneic blood and marrow transplantation (BMT) therapy; and a method for minimizing risks and maximizing benefits of performing allogeneic blood and marrow transplantation (BMT) therapy in a recipient subject, wherein the recipient subject has a hematologic malignancy.