摘要 |
<p>Ribozyme able to cleave a separate substrate RNA molecule, said ribozyme having three base-paired regions generally, but not limited to, in a proposed 'I' configuration, wherein 'upper' and 'lower' based-paired regions comprise between about 4 and 80 bases inclusive of which at least about 50 % are paired with each other, and wherein the 'connecting' region between said upper and lower base paired regions comprises between about 4 and 20 bases inclusive of which at least about 50 % are paired.</p> |