DNA ENCODING A 20 Kd CDK6 INHIBITING PROTEIN

摘要

A nucleic acid encoding a CDK inhibiting protein, particularly a CDK6 inhibiting protein, is selected from the group consisting of: (a) DNA having the nucleotide sequence given herein as SEQ ID NO:1 (which encodes the protein having the amino acid sequence given herein as SEQ ID NO:2), and which are referred to as p20; b) nucleic acids which hybridize to DNA of (a) above and which encode a CDK inhibiting protein; and (c) nucleic acids which differ from the nucleic acids of (a) or (b) above due to the degeneracy of the genetic code, and which encode a CDK inhibiting protein encoded by a nucleic acid of (a) or (b) above. Constructs containing such nucleic acids, cells containing such constructs, proteins encoded by such nucleic acids, antibodies which bind thereto, antisense oligonuclotides corresponding to such nucleic acids, and methods of using the same are also disclosed.