NEW DERIVATIVES OF PYROGLUTAMINIC ACID, PREPARATION PROCESS AND APPLICATIONS

摘要

The new derivatives of pyroglutaminic acid have the formula (I) wherein R<1>, R<2> and R<3> are H or COR<4>, R<4> being lower alkyl or aryl, A<-> is Cl<->, CH3COO<-> and OH<-> and the ondulated line means that the substituent occupies any of the possible spatial positions. The process comprises the reaction of serine with pyridine and acetic anhydrid. These compounds may be applied in inmmunology as modifiers of the biological immune response, in the "integral" treatment of cancer and prevention or treatment of serious systemic infections in "high risk" patients suffering of chronical diseases and secondary immunodeficiency (cancer, AIDS, Diabetes Mellitus), or primary immunodeficiency (syndromes of DiGeorge, Down).