MATERIALS AND METHODS FOR THE TREATMENT OF CANCERS

摘要

The invention provides agents which are capable of manipulating endogenous miRNAs present in cancer cells or modulating the levels of miRNAs in cancer cells such that the behaviour and growth of the cancer can be modified. The invention provides a method of treating cancer using a combination of miRNA-152 inhibition and miRNA 150 expression based on experimental data showing this combination leading to complete growth inhibition of multi-lineage cancers in vivo.