发明名称 |
METHODS FOR ENHANCED PRODUCTION OF BONE MORPHOGENETIC PROTEINS |
摘要 |
Methods and processes for improved recombinant protein production are provided. The methods are useful for production of growth factors, particularly those of the TGF-&bgr; superfamily, including bone morphogenetic proteins (BMPs), such as BMP-2. Suitable host cells are cultured in media where iron is present at a concentration of at least 2.25 μM and if pyridoxal is present, it makes up less than 55% of the molar concentration of vitamin B6 in the media. |
申请公布号 |
HUE027035(T2) |
申请公布日期 |
2016.08.29 |
申请号 |
HUE09733052 |
申请日期 |
2009.04.16 |
申请人 |
Wyeth LLC |
发明人 |
LUAN, Yen-Tung;WANG, Wenge;NYBERG, Gregg;GOMES, Jose, Manuel;DRAPEAU, Denis;CARDOZA, Terry |
分类号 |
C12N5/00;A61K38/18;C07K14/51;C12P21/02 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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