| 发明名称 |
beta -CARBOXY SULFONAMIDE ACAT INHIBITORS |
| 摘要 |
beta -Carboxy sulfonyl compounds of formula (I), wherein R1 is aryl, R3 is hydrogen or alkyl, R3 and R4 are hydrogen or alkyl, Y is -O-, -S-, or -NR2-, and R5 is alkyl or aryl are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT) and are thus useful for treating hypercholesterolemia and atherosclerosis.
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| 申请公布号 |
WO9619446(A1) |
申请公布日期 |
1996.06.27 |
| 申请号 |
WO1995US14009 |
申请日期 |
1995.10.27 |
| 申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
LEE, HELEN, TSENWHEI;PICARD, JOSEPH, ARMAND;SLISKOVIC, DRAGO, ROBERT |
| 分类号 |
C07C311/19;C07C327/22;C07D257/06;(IPC1-7):C07C311/03;C07C311/08;A61K31/18;C07D213/75;C07D213/76 |
主分类号 |
C07C311/19 |
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