发明名称 |
RETROVIRAL AND LENTIVIRAL VECTORS |
摘要 |
The present invention provides a retroviral or lentiviral vector having a viral envelope which comprises: (i) a mitogenic T-cell activating transmembrane protein which comprises a mitogenic domain and a transmembrane domain; and/or (ii) a cytokine-based T-cell activating transmembrane protein which comprises a cytokine domain and a transmembrane domain, wherein the mitogenic or cytokine-based T-cell activating transmembrane protein is not part of a viral envelope glycoprotein. When cells such as T-cells of Natural Killer cells are transduced by such a viral vector, they are simultaneously activated by the mitogenic T-cell activating transmembrane protein and/or the cytokine-based T-cell activating transmembrane protein. |
申请公布号 |
WO2016139463(A1) |
申请公布日期 |
2016.09.09 |
申请号 |
WO2016GB50537 |
申请日期 |
2016.03.01 |
申请人 |
UCL BUSINESS PLC |
发明人 |
PULÉ, Martin;MEKKAOUI, Leila |
分类号 |
C12N15/86;A61K38/00;C07K14/00;C07K16/00 |
主分类号 |
C12N15/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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