Novel parabanic acid derivatives as aldose reductase inhibitors

摘要

A compound is provided represented by the following general formula (I) <CHEM> In the formula, R is hydrogen, C1-4 alkyl or benzyl; X is phenyl which is substituted with trifluoromethyl, cyano, carboxy, carbamoyl, C1-3 alkoxycarbonyl or both nitro and halogen, benzothiazolyl which may be substituted with C1-3 alkyl, C1-3 alkoxy, trifluoromethyl, nitro and/or halogen, naphthyl which may be substituted with nitro and/or halogen, pyridyl which may be substituted with nitro and/or halogen, anthraquinonyl, phthalimide, or thienyl; and n is an integer from 1 to 3. The compounds act as selective inhibitors of aldose reductase. The compounds provided are useful as drugs for therapy and prevention of various types of diabetic complications.