| 摘要 |
PURPOSE: To obtain a hyarulonic acid production promoter containing, as active ingredient, yeast extract, capable of promoting the hyarulonic acid productivity in human skin fibroblast, thus useful for preventing skin aging and treating such diseases as to involve the abnormal decomposition of hyarulonic acid, and safe to the human body. CONSTITUTION: A mixture comprising cetanol, lipophilic monostearic acid glycerin-polyoxyethylene cetyl ether, liquid paraffin, methylpolysiloxane, etc., is first prepared by homogeneously mixing these components at 80 deg.C, and butyl p-oxybenzoate is added to and dissolved in the mixture. Separately, a second mixture comprising sodium N-stearoyl-L-glutamate, dipropylene glycol and water is prepared by homogeneously mixing these components at 80 deg.C, and a yeast extract is added to and dissolved in this mixture. Subsequently, the resultant two solutions are mutually mixed and then cooled to 30 deg.C under through agitation, thus obtaining the objective promoter having the above- mentioned advantages. |
