| 摘要 |
PCT No. PCT/EP92/00716 Sec. 371 Date Oct. 29, 1993 Sec. 102(e) Date Oct. 29, 1993 PCT Filed Mar. 28, 1992 PCT Pub. No. WO92/17213 PCT Pub. Date Oct. 15, 1992.The invention relates to ultrasound contrast agents comprising vesicles comprising a protein capable of formation of gas-containing vesicles, wherein the vesicles contain gas which comprises sulphur hexafluoride or a low molecular weight fluorinated hydrocarbon. These contrast agents exhibit stability in vivo upon administration so as to permit ultrasound visualization while allowing rapid subsequent elimination from the system.
|
