发明名称 |
Opipramol'un hazirlanmasi icin gelistirilmis yöntem. |
摘要 |
An improved method for preparing opipramol (I) is disclosed, wherein iminostilbene (II) is reacted with 1-bromo-3-chloropropane in the presence of a weak base selected from a hydrogen phosphate salt and an acetate salt and in the presence of a phase transfer agent to produce N-(3-halopropyl)iminostilbene (III), which is mixture of N-(3-chloropropyl)iminostilbene and N-(3-bromopropyl)iminostilbene, and then N-(3-halopropyl)iminostilbene is reacted with N-(2-hydroxyethyl)piperazine to form opipramol, as shown in the following equations, where X is chlorine or bromine. <IMAGE> <IMAGE> +TR |
申请公布号 |
TR9501394(A2) |
申请公布日期 |
1996.06.21 |
申请号 |
TR19950001394 |
申请日期 |
1995.11.09 |
申请人 |
TARO PHARMACEUTICAL INDUSTRIES, LTD. |
发明人 |
DANIELLA GUTMAN;MISHEL ASHKAR |
分类号 |
C07D223/22;C07D223/26;(IPC1-7):C07D223/22 |
主分类号 |
C07D223/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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