AMINO ACID DERIVATIVES, MIXTURE OF THEIR ISOMERS AND SEPARATE ISOMERS AND THEIR SALTS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION

摘要

FIELD: biochemistry, organic chemistry, pharmacy. SUBSTANCE: product: amino acid derivatives of the general formula(I) where R- vinyl, aryl, heteroaryl, etc.; Ais L- or D-amino acid; B - group A-NRRor -Rwhere A- lipophilic amino acid containing unsubstituted phenyl or phenyl substituted with 1-3 similar or different substituents. Also, invention relates with a method of synthesis of amino acid derivatives of formula (I) mentioned above. Method involves the by-step condensation of the corresponding amino acid or partial sequences of peptide derivatives, carboxylic acids and amines by known procedures and synthesized compound is isolated as a free substance, as isomer mixture or separate isomers or as a salt, and also the pharmaceutical composition containing amino acid derivatives of formula (I) mentioned above as an active substance taken at effective amount and if necessary pharmaceutically acceptable carrier. EFFECT: improved method of synthesis.