A TGF-BETA SUPERFAMILY TYPE II RECEPTOR HAVING BINDING AFFINITY
摘要
The present invention relates to a novel TGF- beta superfamily type II receptor having binding affinity for a bone morphogenic protein, osteogenic protein 1 (OP-1). The novel type II receptor has a serine/threonine kinase domain followed by a long serine and threonine rich region in the C-terminal end. The invention further provides nucleic acids encoding the novel type II receptor as well as vectors and host cells expressing the nucleic acids and recombinant production methods using the nucleic acids. Complexes of the novel type II receptor with an appropriate TGF- beta superfamily type I receptor are also provided.
申请公布号
WO9618735(A2)
申请公布日期
1996.06.20
申请号
WO1995US16412
申请日期
1995.12.14
申请人
AMGEN BOULDER INC.;LUDWIG INSTITUTE FOR CANCER RESEARCH