摘要 |
<p>The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structureX-Y-Leu-Phe-[Z]n-Wwherein: X is an amino protecting group, Y is an amino acid residue, Z is a spacer sequence, n is 0 or 1, and W is a labeling or attachment substituent.</p> |
申请人 |
THE GENERAL HOSPITAL CORPORATION;ORTHO PHARMACEUTICAL CORPORATION;JOHNSON MATTHEY, INC. |
发明人 |
FISCHMAN, ALAN J.;SOLOMON, HOWARD F.;DERIAN, CLAUDIA K.;BRIDGER, GARY J.;HIGGINS, III., JOHN D.;LARSEN, SCOTT K.;HERNANDEZ, PEDRO E.;RUBIN, ROBERT H.;STRAUSS, WILLIAM H.;FUCCELLO, ANTHONY J.;KROON, DANIEL J.;RIEXINGER, DOUGLAS |