| 摘要 |
A matrix type patch formulation which comprises an adhesive layer containing a physiological active substance, an organic acid, a hydrophobic high molecular material, a tackifying resin, a plasticizer and an absorption enhancer, is disclosed. The adhesive layer preferably contains 0.1 to 20 %(w/w) of the physiological active substance, 0.01 to 15 %(w/w) of the organic acid, 15 to 60 %(w/w) of the hydrophobic high molecular material, 10 to 70 %(w/w) of the tackifying resin, 10 to 60 %(w/w) of the plasticizer and 0.01 to 20 %(w/w) of the absorption enhancer. The organic acid is preferably an aliphatic carboxylic acid, an aromatic carboxylic acid, an alkyl sulfonic acid, an alkyl sulfonic acid derivative, cholic acid derivative or a water-soluble inorganic salt thereof. The matrix type patch formulation of the present invention can increase the percutaneous absorbability of the physiological active substance and is extremely reduced in skin irritation. |
