| 摘要 |
PCT No. PCT/EP95/04678 Sec. 371 Date Jul. 9, 1997 Sec. 102(e) Date Jul. 9, 1997 PCT Filed Nov. 28, 1995 PCT Pub. No. WO96/16971 PCT Pub. Date Jun. 6, 1996Disclosed is a novel method of producing optically active metallocenyl phosphines of the general formula shown In the formula (Ia) (Ib), M represents iron, ruthenium or nickel; R1 and R1' both represent C1-C4 alkyl groups; R2 and R3 each represent independently of each other either hydrogen or a C1-C4 alkyl group, or, together with the nitrogen atom, form a five- or six member saturated heterocyclic ring which may optionally contain further heteroatoms; R4 and R5 each represent independently of each other a C1-C4 alkyl group (for example) or an aryl group which is optionally substituted with one or more methyl or methoxy groups or with one or more fluorine atoms. These are obtained from acyl- or 1,1'-diacylmetallocenes by enantioselective reduction with borane in the presence of optically active oxazoborolidines, esterification of the metallocenyl alkanols thus obtained, nucleophilic substitution of the ester group with a secondary amine, lithiation and reaction with a phosphine halide. |
