INGESTIBLE POLYMERIC PHOSPHONIUM SALTS FOR THE LOWERING OF BLOOD CHOLESTEROL

摘要

The invention is concerned with novel ingestible polymeric phosphonium salts having the formulas: P'-t(CH2)n1P+(R)2!m1¢(CH2)n2P+(R)2!m2R (Ib) or (Ic) wherein P' represents a cross-linked and non-digestible polymer backbone; R is a lower alkyl radical; X- is a pharmaceutically acceptable anion; m1 and m2 are, independently, integers varying from 0 to 5 inclusive, with the proviso thatin formula (Ia) ml + m2 are, independently, integers varying from 0 to 6 inclusive, with the proviso that when m1 P2, q1 and q2 are, independently, integers varying from 1 to 6 inclusive. The polymeric phosphonium salts of the invention are highly efficient sorbents for bile acids and salts and can thus be used for reducing hypercholesterolemia in affected humans.