发明名称 |
Anti-CD3 antibody-aminodextran conjugates for induction of T-cell activation and proliferation |
摘要 |
The invention describes the use of novel aminodextran compounds containing about 5-20% by weight amine groups to bind a plurality of monoclonal antibodies. The resulting antibody-aminodextran compounds may be used to induce the activation and proliferation of selected mammalian cells. Specific examples are given using an anti-CD3 monoclonal antibody conjugated two aminodextrans containing about 5% and 16%, respectively, by weight amine groups as an agent for inducing the activation and proliferation of T cells.
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申请公布号 |
US5527713(A) |
申请公布日期 |
1996.06.18 |
申请号 |
US19950504327 |
申请日期 |
1995.07.19 |
申请人 |
COULTER CORPORATION |
发明人 |
BOLTON, WADE E.;MAPLES, JOHN A.;SIIMAN, OLAVI;KENYON, NORMA S.;HEALY, CYNTHIA G. |
分类号 |
G01N33/50;A61K47/48;A61K49/00;C07K16/28;C07K17/10;C12P21/08;G01N33/53;G01N33/531;G01N33/569;(IPC1-7):G01N33/548 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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