| 摘要 |
PCT No. PCT/GB92/01666 Sec. 371 Date Aug. 1, 1994 Sec. 102(e) Date Aug. 1, 1994 PCT Filed Sep. 11, 1992 PCT Pub. No. WO93/06236 PCT Pub. Date Apr. 1, 1993.A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centers which comprises selective reaction of at least one isomer with a reagent catalyzed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyran-2-one is of Formula (1): <IMAGE> Formula (1) wherein: Z is -H or a protecting group susceptible of reaction with the reagent under the influence of the enzyme; and Y is formyl or protected formyl.
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