发明名称 |
Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria |
摘要 |
Pyridone carboxylic acid compounds or physiologically hydrolyzable esters thereof are provided which are represented by the formula: <IMAGE> (I) wherein R1 is a lower alkyl, a halogen-substituted lower alkyl, a lower alkenyl, a cycloalkyl, or a substituted- or unsubstituted-phenyl group; R2 is a hydrogen atom, or a lower alkyl or an amino group; A is a nitrogen atom or the group C-X wherein X is a hydrogen or a halogen atom, or an alkoxy group; and Z is a group having the formula: <IMAGE> (IV) wherein n is 1 or 2; R3 and R4 each represent a hydrogen atom or a lower alkyl group, with proviso that, if n is 2, one of R3 and R4 is a hydrogen atom; R5 and R6 each represent a hydrogen atom, or a hydroxy, a lower alkoxy or an amino group which is unsubstituted or substituted by a lower alkyl group, with proviso that one of R5 and R6 is a hydrogen atom; and R7 is a hydrogen atom or a lower alkyl group. The compounds of the present invention show potent and broad spectrum of antibacterial activities.
|
申请公布号 |
US5527910(A) |
申请公布日期 |
1996.06.18 |
申请号 |
US19930160821 |
申请日期 |
1993.12.03 |
申请人 |
CHEIL FOODS & CHEMICALS, INC. |
发明人 |
KIM, CHOONG S.;KIM, JIN W.;LEE, JAE M.;CHO, IL H.;YOUN, YONG S.;SHIN, YOUNG J.;LEE, KI H.;KIM, JE H.;JUNG, YONG H.;AN, SEUNG H. |
分类号 |
C07D221/04;A61K31/4375;A61K31/44;A61K31/4427;A61K31/4439;A61K31/47;A61K31/4709;A61K31/472;A61K31/4725;A61K31/473;A61P31/04;C07D209/52;C07D401/04;C07D401/14;C07D471/04;(IPC1-7):C07D401/14;C07D498/06 |
主分类号 |
C07D221/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|