PRODUCTION OF AMIDE COMPOUND

摘要

PURPOSE: To provide a method for producing an amide compound by which the stabler amide compound can be produced even in accumulating the amide compound in a reactional solution at a high concentration. CONSTITUTION: This method for producing an amide compound comprises a step for converting an immobilized microorganism prepared by immobilizing a microorganism having hydrating activities in converting a nitrile compound into the amide compound into particles having 250-1000μm diameter before reacting the nitrile compound with the immobilized microorganism and treating the resultant fine particles with a water-soluble dialdehyde at 0.2-1.0wt.% final concentration in the method for reacting the nitrile compound with the immobilized microorganism and converting the nitrile compound into the amide compound. Furthermore, this method for improving the stability of the hydrating activities in converting the nitrile compound into the amide compound is provided. The immobilized microorganism is improved in the stability of the hydrating activities in converting the nitrile compound into the amide compound.