| 摘要 |
An oral preparation comprises a solid compsn. contg. at least one active agent (I), at least one disintegrant, pharmaceutical adjuvants, and a component (II) that accelerates the disintegration of the compsn. in the mouth or in liquids. (II) is a water-soluble cpd. that is an amino acid, its salt and/or its deriv. Pref. the disintegrant is starch, cellulose, alginic acid, casein, and/or derivs. of these and/or insol. polyvinyl pyrrolidone. (II) is glycine, proline, hydroxyproline, lysine and/or their salts and/or derivs. Pref. the prepn. contains a hydrophilic (I) embedded in or coated with hydrophobic material. The hydrophobic material is a matrix or coating of shellac, stearic acid, gelatin, zein, gum arabic, cellulose deriv., acrylic acid polymer and/or vinyl acetate polymer. |
