Cyclic derivatives of the vasoactive intestinal peptide their preparation and pharmaceutical compositions containing them

摘要

The present invention relates to vasoactive peptide (VIP) analogs wherein the side chain carboxy terminus of one amino acid in the peptide chain is attached covalently to the side chain amino terminus of another amino acid in the peptide chain via the formation of an amide bond. The covalent bonding between the two amino acid residues in the peptide chain yields a ring structure. The present invention provides cyclic vasoactive peptides and pharmaceutical compositions comprising such a cyclic vasoactive peptide for the treatment of bronchotracheal constrictive disorders.