| 发明名称 |
Polypeptide having an amino acid replaced with N-benzylglycine |
| 摘要 |
The present invention relates to one or more polypeptides having useful biological activity in a mammal, which comprise: a polypeptide related to bradykinin of four to ten amino acid residues wherein one or more specific amino acids in the polypeptide chain are replaced with achiral N-benzylglycine. These polypeptide analogues have useful potent agonist or antagonist pharmacological properties depending upon the structure. A preferred polypeptide is (N-benzylglycine7)-bradykinin.
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| 申请公布号 |
US5527882(A) |
申请公布日期 |
1996.06.18 |
| 申请号 |
US19940335202 |
申请日期 |
1994.11.07 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
MITCHELL, ALEXANDER R.;YOUNG, JANIS D. |
| 分类号 |
C07K7/14;C07K7/16;C07K7/18;C07K7/23;C07K7/64;C07K14/575;C07K14/595;(IPC1-7):A61K38/00;C07K7/00;C07K7/06 |
主分类号 |
C07K7/14 |
| 代理机构 |
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代理人 |
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