Anti-tumor platinum complexes, their preparation and their therapeutic use

摘要

Compounds of formula (I): <IMAGE> (I) in which: A and B are separately monoamines or together diamines; and Z is a group of formula (II) or (III): <IMAGE> (II) <IMAGE> (III) (in which R1, R2 and R7 are various organic groups, n is 0, 1 or 2 and X is a direct carbon-carbon bond or lower alkylene) show valuable anti-tumor activity and may be prepared by reacting an amine-platinum complex with a compound providing the group represented by Z.