| 摘要 |
Therapeutic agents for osteoporosis comprising, as an active ingredient, a triazepine compound of the formula ÄIÜ <CHEM> wherein R<1> is aryl or heteroaryl; R<2> is hydrogen atom, hydroxy, halogen atom or lower alkyl; R<4> is hydrogen atom or halogen atom, or R<2> and R<4> form carbonyl combinedly together with the carbon atom to which they bond; R<3> is hydrogen atom, lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, -X-Y wherein X is -(CH2)m-, -CO-, -COCH2-, -NH-, -NHCH2-, -CH2NH-, -CH2NHCO-, -OCH2-, -(CH2)nO- or -CH2S- and Y is halogen atom, cycloalkyl, aryl or heteroaryl; and A is benzene ring or thiophene ring, or a salt thereof, novel triazepine compounds, and intermediate triazepine compounds for producing these triazepine compounds. The triazepine compounds of the formula ÄIÜ have superior bone resorption-inhibitory action and are useful as therapeutic agents for osteoporosis. |
