| 摘要 |
The present invention relates to diethylenetriaminepentaacetic acid (DTPA):protein compositions wherein the chelating agent DTPA has been conjugated site-specifically to the N-terminus of the protein, thereby providing a homogenous and well-defined product capable of forming complexes with a variety of metallic radionuclides. The compositions of the present invention can be produced in large quantities and retain full in vivo bioactivity, either with or without chelated metallic radionuclide. The compositions may have potential use in diagnosis, imaging, and/or treatment of leukemia and related diseases. |
