发明名称 |
CLONING AND RECOMBINANT PRODUCTION OF CRF RECEPTOR(S) |
摘要 |
In accordance with the present invention, there are provided novel G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of the binding sites of said receptor protein. Nucleic acid sequences encoding such receptors, assays employing same, as well as antibodies derived therefrom, are also disclosed. Invention CRF-Rs can be employed in a variety of ways, such as, for example, in bioassays, for production of antibodies thereto, in therapeutic compositions containing such proteins and/or antibodies.
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申请公布号 |
CA2180957(A1) |
申请公布日期 |
1996.06.13 |
申请号 |
CA19952180957 |
申请日期 |
1995.12.06 |
申请人 |
SALK INSTITUTE FOR BIOLOGICAL STUDIES (THE) |
发明人 |
PERRIN, MARILYN H.;CHEN, RUOPING;LEWIS, KATHY A.;VALE, WYLIE W., JR.;DONALDSON, CYNTHIA J.;SAWCHENKO, PAUL |
分类号 |
G01N33/53;A61K38/00;C07K14/72;C07K16/28;C12N15/09;C12N15/12;C12P21/02;C12Q1/68;G01N33/566;(IPC1-7):C12N15/18;C12Q1/04 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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