Oligo:nucleotide conjugate with metal chelating residue for NMR diagnosis

摘要

Oligonucleotide conjugate (A) comprises an oligonucleotide radical (N) with n substits. B-K, the new feature being that N is modified to prevent or inhibit degradation by natural nucleases. B = direct bond or linker; and K= complexing agent, opt. carrying an element of atomic no. 21-29, 42, 44 or 58-70.