PROCESSES FOR PRODUCING ISOTHIAZOLE DERIVATIVES

摘要

A process for producing a 1,2-benzisothiazole by the reaction of a 2-(alkylthio)benzaldehyde oxime with a halogen compound; a process for producing a 3-halo-1,2-benzisothiazole by the reaction of a 1,2-benzisothiazole with a halogenating agent; and a process for producing a 1-(1,2-benzisothiazol-3-yl)-piperazine by the reaction of the 3-halo-1,2-benzisothiazole thus obtained with a piperazine. It is possible according to these processes to produce 1,2-benzisothiazoles, 3-halo-1,2-benzisothiazoles and, further therefrom, 1-(1,2-benzisothiazol-3-yl)-piperazines, each being useful as intermediates for medicines such as remedies for mental illness, readily in high yields through shorter process steps without the necessity for using expensive starting materials.