摘要 |
<p>The invention provides a 12-kDa PPD protein isolated and purified from the purified protein derivative (PPD), the major fraction of Mycobacterium tuberculosis that protects mice against the induction of experimental autoimmune encephalomyelitis (EAE), and salts, functional derivatives, analogs and active fractions thereof, and pharmaceutical compositions comprising them for the treatment of autoimmune diseases.</p> |