| 摘要 |
Cpds. of formula (I) are new. In (I), R1 = 1-25C alkyl, 2-24C alkenyl, 5-12C cycloalkyl or cycloalkenyl (opt. substd. with R = 1-4C alkyl), phenyl (opt. substd. with R as above), 7-9C phenylalkyl or -CH2-S-X1; R2 = as for R1, or also -(CH2)pCOOX2 or -(CH2)qOX3; R3 = H or 1-4C alkyl; R4 = H or 1-8C alkyl; R5 = H, 1-10C alkyl, Ph, -CH2COOX4, or -CN; R6 = H, 1-4C alkyl, Ph, -COOX5, -CN or -CONX6X7; R7 = H or 1-10C alkyl; R8 = H, 1-4C alkyl or Ph; X1 - 1-25C alkyl, opt. R-substd. 5-12C cycloalkyl, opt. R-substd. Ph, 7-9C phenylalkyl or -(CH2)rCOOY1; X2, X4, X5 = as for X1, but not -(CH2)rCOOY1; X3 = as for X2, X4, X5, and also 1-25C alkanoyl, 3-25C alkenoyl, 3-25C alkanoyl with in-chain O, S or -NY2, 6-9C cycloalkyl- carbonyl, opt. R-substd. benzoyl, or thenoyl or furoyl; X6, X7 = H, 1-25C alkyl, opt. R-substd. 5-12C cycloalkyl, 5-12C cycloalkenyl or Ph, or 7-9C phenylalkyl; Y1 = 1-25C alkyl, opt. R-substd. 5-12C cycloalkyl or pH, or 7-9C phenylalkyl; Y2 = H or 1-8C alkyl; p = 0, 1 or 2; q = 0-8; r = 1 or 2; n = 1-4; if n = 1, A = -OZ1, -NZ2Z3, -NH(OZ4), -ON=CZ5Z6, -SOmZ7, -NHZ8 or -SZ8, or A = opt. R-substd. heterocyclic gp. with the free valency on N; Z1 = H, 1-25C alkyl, 3-25C alkyl with in-chain O, S or NY2, 3-24C alkenyl, 5-20C satd. monocyclic hydrocarbyl, 7-20C satd. bicyclic hydrocarbyl, 10-20C satd. tricyclic hydrocarbyl, opt. R-substd. 5-12C cycloalkenyl, 7-9C phenylalkyl (opt. ring-substd. with R), tetrahydro-furfuryl or -abietyl, 1-25C alkanoyl, 3-25C alkenoyl, 3-25C alkanoyl with in-chain O, S or NY2, 6-9C cycloalkylcarbonyl, opt. R-substd. benzoyl, thenoyl, furoyl, or a gp. of formula (IIa) or (IIb); Z2 = H, 1-25C alkyl, OH-substd. 2-25C alkyl, 3-24C alkenyl, opt. R-substd. 5-12C cycloalkyl or Ph, 7-9C phenylalkyl, 1-25C alkanoyl, 3-25C alkenoyl, 3-25C alkanoyl with in-chain O, S or NY2, 6-9C cycloalkylcarbonyl, opt. R-substd. benzoyl, thenoyl, furoyl, -(CH2)pCOOX2 or a gp. of formula (IIb); Z3 = 1-25C alkyl, OH-substd. 2-25C alkyl, 3-24C alkenyl, opt. R-substd. 5-12C cycloalkyl or Ph, 7-9C phenylalkyl or a gp. (IIb); or Z2 + Z3 = 3-6C alkylene, 3-6C oxo-alkylene, or 3-6C alkylene with in-chain O, S or -NT6; Z4 = 1-25C alkyl, opt. R-substd. 5-12C cycloalkyl or Ph, or 7-9C phenylalkyl; Z5, Z6 = H, 1-25C alkyl, 2-24C alkenyl, opt. R-substd. 5-12C cycloalk(en)yl or Ph, or 7-9C phenylalkyl; or Z5 + Z6 + C = opt. R-substd. 5-12C cycloalkylidene ring; Z7 = 1-25C alkyl, opt. R-substd. 5-12C cycloalkyl or Ph, or -(CH2)rCOOY1; Z8 = opt. R-substd. 2-benzoxazolyl or 2-benzthiazolyl; T1, T2 = as for Z5/Z6, or also -CH2-S-X1; T3 = H or 1-4C alkyl; T4 = as for Z5/Z6, or also -CH2SX1, -(CH2)pCOOX2 or -(CH2)qOX3; T5 = 1-8C alkyl, OH-substd. 2-4C alkyl, O, OH, -NO, -CH2CH, 1-18C alkoxy, 5-12C cycloalkoxy, 3-6C alkenyl, 7-9C phenylalkyl (opt. ring-substd. with R), 1-8C alkanoyl, 3-8C alkenoyl or benzoyl; T6 = 1-12C alkyl, opt. R-substd. 5-12C cycloalkyl or pH, or 7-9C phenylalkyl; m = 1 or 2; w = 0 or 1; etc., with further provisos. |
