发明名称 Detection and therapy of lesions with biotin/avidin conjugates
摘要 Methods are provided for detecting and/or treating lesions in a patient. The methods use a targeting composition comprised of a biotin and targeting protein conjugate or an avidin and targeting protein conjugate; optionally, a clearing composition comprised of avidin, when the targeting composition is a biotin conjugate, or biotin, when the targeting composition is a avidin conjugate; a detection or therapeutic composition comprised of a conjugate of avidin or biotin with a targeting protein and detection or therapeutic agent; and, optionally, another detection or therapeutic composition comprised of avidin or biotin conjugated to a detection or therapeutic agent. Compositions and kits useful in the methods are also provided.
申请公布号 US5525338(A) 申请公布日期 1996.06.11
申请号 US19920933982 申请日期 1992.08.21
申请人 IMMUNOMEDICS, INC. 发明人 GOLDENBERG, DAVID M.
分类号 G01N33/50;A61K31/415;A61K31/70;A61K38/00;A61K39/395;A61K45/00;A61K47/48;A61K49/00;A61K49/16;A61K51/00;A61K51/10;A61P9/00;A61P29/00;A61P31/04;A61P35/00;A61P35/02;C12Q1/00;G01N33/53;G01N33/531;G01N33/532;G01N33/534;G01N33/547;G01N33/563;G01R33/28;(IPC1-7):A61K38/18;A61K38/27;A61K39/385;A61K39/44 主分类号 G01N33/50
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