发明名称 |
Cytolysin gene and gene product |
摘要 |
A Salmonella gene, encoding a cytolysin, has been identified by screening for hemolysis on blood agar. The gene (slyA) is present in every strain of Salmonella examined in Shigella, and enteroinvasive Escherichia coli (EIEC) but not in other enterobacteriaceae. It is encoded near 28.5 minutes on the chromosome. A SlyA (salmolysin) has hemolytic and cytolytic activity and has a molecular weight predicted by the DNA sequence. LD50 and infection kinetics data in mice indicate that the toxin is required for virulence and facilitates Salmonella survival within peritoneal macrophages.
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申请公布号 |
US5525504(A) |
申请公布日期 |
1996.06.11 |
申请号 |
US19930054480 |
申请日期 |
1993.04.30 |
申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG |
发明人 |
GOEBEL, WERNER;LIBBY, STEPHEN J.;HEFFRON, FRED |
分类号 |
C07K14/255;(IPC1-7):C12N1/21;C12N15/31;C12N15/33 |
主分类号 |
C07K14/255 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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