MORPHOLINOETHYLAMIDE DERIVATIVES

摘要

According to the invention, compounds of formula (I), wherein R1 is an acyl radical selected from lower alkoxy-lower alkanoyl (including lower alkoxy-carbonyl) wherein the lower alkoxy radical is unsubstituted or substituted by halogen, phenyl or lower alkoxy; or by a heterocyclic radical selected from piperidinyl, pyrrolidinyl, tetrahydropyranyl, tetrahydrofuranyl, thiazolidinyl, thiazolyl, indolyl and 4H-1-benzopyranyl, each of which is unsubstituted or substituted by oxo, hydroxy, amino, lower alkyl, lower alkoxycarbonyl and/or phenyl-lower alkoxycarbonyl; lower alkanoyl which is unsubstituted or substituted by one of the last-mentioned unsubstituted or substituted heterocyclic radicals; and arylcarbonyl or heterocyclylcarbonyl each substituted by heterocyclyl or by heterocyclyl-lower alkyl; or is the residue of an amino acid defined in the description (which is non-acylated or N-acylated by an acyl radical mentioned above); R2 and R3 are each independently of the other cyclohexyl, cyclohexenyl, phenyl, naphthyl or tetrahydronaphthyl, each of which is unsubstituted or substituted by lower alkyl, phenyl-lower alkyl, halogen, halo-lower alkyl, cyano, hydroxy, lower alkoxy, phenyl-lower alkoxy, pyridyl-lower alkoxy, lower alkoxy-lower alkoxy, lower alkoxy-carbonyl-lower alkoxy, carboxy-lower alkoxy, hydroxy-lower alkoxy having at least 2 carbon atoms, wherein hydroxy is not bonded in the 1-position, carbamoyl-lower alkoxy, cyano-lower alkoxy, morpholinyl-lower alkoxy, lower alkylenedioxy, or phenyl-lower alkanesulfonyl which is unsubstituted or substituted in the phenyl radical by halogen; or lower alkyl, R4 is lower alkyl, cyclohexyl or phenyl, and R5, R5', R6, R7, R8, R8', R9 and R10 are each independently of the others hydrogen or lower alkyl, or salts thereof, which have anti-retroviral activity, are described.