THROMBOCYTOTIC FACTOR

摘要

An object of the present invention is to provide a physiologically active substance having activity in acting on the megakaryocyte-platelet system, in promoting the differentiation and maturation of megakaryocytes, and in promoting the formation of platelets. The present invention relates to a thrombocytopoiesis stimulating factor, characterized in having the following amino acid sequence in its molecule, and to a medicinal composition for treating thrombocytopenia, characterized in containing said thrombocytopoiesis stimulating factor as an active component: xaa Gly Asn Asn Asp Glu Ser Asn Ile Ser Phe Lys Glu Lys Asp Ile (where Xaa indicates that the amino acid is unspecified). The aforementioned physiologically active substance is useful as an active component or the like in therapeutics and preventives for thrombocytopenia and thrombocytopenic purpura associated with chemotherapy and marrow grafts, and for various other diseases which are prone to bleeding attributed to thrombocytopenia.