LOW MOLECULAR WEIGHT THROMBOPOIETIN

摘要

Isolated mammalian thrombopoietins are disclosed. The thrombopoietins include polypeptides characterized by an amino acid sequence selected from the group consisting of (a) a sequence of amino acids as shown in SEQ ID NO:2 having an amino terminus at Ser(45) and a carboxyl terminus between Ser(208) and Asn(216), inclusive; a sequence of amino acids as shown in SEQ ID NO:4 having an amino terminus at Ser(22) and a carboxyl terminus between Arg(185) and Asn(193), inclusive; a sequence of amino acids as shown in SEQ ID NO:4 having an amino terminus at Ser(22) and a carboxyl terminus at Arg(198); a sequence of amino acids as shown in SEQ ID NO:4 having an amino terminus at Ser(22) and a carboxyl terminus at Phe(207); and allelic variants of (a)-(d). Also disclosed are isolated DNA molecules encoding these polypeptides as well as vectors, cells and methods that can be used for the production of the polypeptides.