REAGENTS AND PROCESSES FOR TARGETING MUTANT EPIDERMAL GROWTH FACTOR RECEPTORS

摘要

Cell lines are provided for the overexpression of Type III mutant EGF receptor. Method of producing these cell lines are also provided. In addition, antibodies raised against peptides expressed by these cell lines are provided. Vaccines comprising peptides from a fusion junction present in a mutant human EGF receptor and methods of using these vaccines in the inhibition of tumor formation and enhancement of tumor regression are also provided. Further, antisense oligonucleotides targeted to a mutant EGF receptor which decreases expression of a mutant EGF receptor are disclosed.