Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines and their use as medicaments

摘要

PCT No. PCT/EP95/04393 Sec. 371 Date Apr. 22, 1997 Sec. 102(e) Date Apr. 22, 1997 PCT Filed Nov. 8, 1995 PCT Pub. No. WO96/15129 PCT Pub. Date May 23, 1996The invention is concerned with basically-substituted imidazodiazepinones of the formula: I wherein A and the two carbon atoms denoted by alpha and beta together signify: (A1) Q signifies one of the residues: (Q1) (Q2) (Q3) R1 and R2 each signify hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower hydroxyalkyl, lower alkoxy-lower alkyl, (C3-C6)-cycloalkyl, (C3-C6)-cycloalkyl-lower alkyl, amino-lower alkyl, lower alkylamino-lower alkyl, di-lower alkylamino-lower alkyl or aryl-lower alkyl or together with the nitrogen atom signify a 5- to 8-membered heterocycle optionally containing a further hetero atom or a fused benzene ring; R3 signifies hydrogen and R4 signifies lower alkyl or R3 and R4 together signify a di- or trimethylene group and; R5 and R6 each signify hydrogen, halogen, trifluoromethyl, lower alkoxy or nitro; with the carbon atom denoted by gamma having the S-configuration when R3 is different from hydrogen, and pharmaceutically acceptable acid addition salts thereof. These compounds can be used as anxiolytic and/or anticonvulsant and/or muscle relaxant and/or sedative-hypnotic active substances.