发明名称 |
Preparation process of aminoacetamide derivative |
摘要 |
<p>Disclosed herein are novel processes for preparing aminoacetamide derivatives, wherein: (1) a secondary amine is reacted with a 2-haloacetamide in the presence or absence of at least one solvent selected from water, lower alcohols, aromatic solvents and acetic acid esters; (2) an N-benzylideneamine derivative is reacted with dimethyl sulfate or diethyl sulfate to form a secondary amine, and this secondary amine is then reacted with a 2-haloacetamide; and (3) a primary amine is reacted with benzaldehyde to form an N-benzylideneamine derivative, this product is then reacted with dimethyl sulfate or diethyl sulfate to form a secondary amine, and this secondary amine is further reacted with a 2-haloacetamide. The 2-aminoacetamide derivatives are useful as intermediates for the preparation of novel antibiotics.</p> |
申请公布号 |
EP0714885(A2) |
申请公布日期 |
1996.06.05 |
申请号 |
EP19950118060 |
申请日期 |
1995.11.16 |
申请人 |
EISAI CHEMICAL CO., LTD. |
发明人 |
SEKI, CHIAKI;ISHIZAWA, SHOZO;KOIWA, ATSUSHI;OGURA, TOSHIMASA;TAKAHA, MOTOSHIGE;UCHIYAMA, MANABU |
分类号 |
C07C231/12;C07C237/06;(IPC1-7):C07C231/14;C07C237/04 |
主分类号 |
C07C231/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|