Recombinant Alzheimer's amyloid protein protease inhibitor

摘要

An analog of human amyloid plaque core protein protease inhibitor wherein the amino acid corresponding to arginine at position 13 in the sequence $is\; substituted\; with\; an\; aromatic\; amino\; acid,\; said\; analog\; exhibiting\; chymotrypsin\; inhibitory\; activity\; or\; is\; substituted\; with\; a\; neutral\; hydrophobic\; amino\; acid,\; said\; analog\; exhibiting\; human\; elastase\; inhibitory\; activity\; and\; method\; of\; producing\; them.\; Use\; of\; the\; protease\; inhibitor\; in\; the\; manufacture\; of\; a\; medicament\; for\; use\; in\; treating\; acute\; pancreatitis\; and\; method\; of\; recovering\; purified\; protease\; inhibitor.$