| 摘要 |
The present invention provides a compound of formula I <IMAGE> (I) wherein R1 is H, OH, halo, OCO(C1-C6 alkyl), OCO(aryl), OSO2(C4-C6 alkyl), OCOO(C1-C6 alkyl), OCOO(aryl), OCONH(C1-C6 alkyl), or OCON(C1-C6 alkyl)2; R2 is aryl, C1-C6 alkyl, C3-C6 cycloalkyl, or 4-cyclohexanol; R3 is O(CH2)2 or O(CH2)3; R4 and R5 are optionally CO(CH2)2CH3, CO(CH2)3CH3 C1-C6 alkyl, or R4 and R5 combine to form, with the nitrogen to which they are attached, piperidine, morpholine, pyrrolidine, 3-methylpyrrolidine, 3,3-dimethylpyrrolidine, 3,4-dimethylpyrrolidine, azepine, or pipecoline; R6 is >CH(C1-C5 alkyl), >CH(C2-C5 alkenyl), >C=CH(C1-C5 alkyl) >CH(aryl), >C(OH)(C1-C5 alkyl), >C(OH)(C2-C5 alkenyl), >C(OH)aryl; and pharmaceutically acceptable salts thereof.
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