| 摘要 |
A class of N-substituted piperazine, piperidine and tetrahydropyridine derivatives of formula (I), further substituted at the 4-position by an optionally substituted aryl-alkyl or heteroaryl-alkyl moiety, are selective agonists of 5-HT1-like receptors, being potent agonists of the human 5HT1D.alpha. receptor subtype relative to the 5-HT1D.beta. subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists. In formula (I) Z represents hydrogen, halogen, cyano, nitro, trifluoromethyl, -OR5, -OCOR5, -OCONR5R6, -OCH2CN, OCH2CONR5R6, -SR5, -SOR5, SO2R5, -SO2NR5R6, -NR5R6, -NR5COR6, -NR5CO2R6, NR5SO2R6, -COR5, -CO2R5, -CONR5R6, or a group of formula (a), (b), (c) or (d).
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